If you have or will have any domain controllers running Windows NT 4.0 and earlier, then do not raise the domain functional level to Windows 2000 native. Once the domain functional level is set to Windows 2000 native, it cannot be changed back to Windows 2000 mixed.
If you have or will have any domain controllers running Windows NT 4.0 and earlier or Windows 2000, then do not raise the domain functional level to Windows Server 2003. Once the domain functional level is set to Windows Server 2003, it cannot be changed back to Windows 2000 mixed or Windows 2000 native.